	   SnapGene      %GACGAAAGGGCCTCGTGATACGCCTATTTTTATAGGTTAATGTCATGATAATAATGGTTTCTTAGACGTCAGGTGGCACTTTTCGGGGAAATGTGCGCGGAACCCCTATTTGTTTATTTTTCTAAATACATTCAAATATGTATCCGCTCATGAGACAATAACCCTGATAAATGCTTCAATAATATTGAAAAAGGAAGAGTATGAGTATTCAACATTTCCGTGTCGCCCTTATTCCCTTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAACTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGCGCGGTATTATCCCGTATTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTGAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACTCGCCTTGATCGTTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGTAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGGTCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTACTCATATATACTTTAGATTGATTTAAAACTTCATTTTTAATTTAAAAGGATCTAGGTGAAGATCCTTTTTGATAATCTCATGACCAAAATCCCTTAACGTGAGTTTTCGTTCCACTGAGCGTCAGACCCCGTAGAAAAGATCAAAGGATCTTCTTGAGATCCTTTTTTTCTGCGCGTAATCTGCTGCTTGCAAACAAAAAAACCACCGCTACCAGCGGTGGTTTGTTTGCCGGATCAAGAGCTACCAACTCTTTTTCCGAAGGTAACTGGCTTCAGCAGAGCGCAGATACCAAATACTGTTCTTCTAGTGTAGCCGTAGTTAGGCCACCACTTCAAGAACTCTGTAGCACCGCCTACATACCTCGCTCTGCTAATCCTGTTACCAGTGGCTGCTGCCAGTGGCGATAAGTCGTGTCTTACCGGGTTGGACTCAAGACGATAGTTACCGGATAAGGCGCAGCGGTCGGGCTGAACGGGGGGTTCGTGCACACAGCCCAGCTTGGAGCGAACGACCTACACCGAACTGAGATACCTACAGCGTGAGCTATGAGAAAGCGCCACGCTTCCCGAAGGGAGAAAGGCGGACAGGTATCCGGTAAGCGGCAGGGTCGGAACAGGAGAGCGCACGAGGGAGCTTCCAGGGGGAAACGCCTGGTATCTTTATAGTCCTGTCGGGTTTCGCCACCTCTGACTTGAGCGTCGATTTTTGTGATGCTCGTCAGGGGGGCGGAGCCTATGGAAAAACGCCAGCAACGCGGCCTTTTTACGGTTCCTGGCCTTTTGCTGGCCTTTTGCTCACATGTTCTTTCCTGCGTTATCCCCTGATTCTGTGGATAACCGTATTACCGCCTTTGAGTGAGCTGATACCGCTCGCCGCAGCCGAACGACCGAGCGCAGCGAGTCAGTGAGCGAGGAAGCGGAAGAGCGCCCAATACGCAAACCGCCTCTCCCCGCGCGTTGGCCGATTCATTAATGCAGCTGGCACGACAGGTTTCCCGACTGGAAAGCGGGCAGTGAGCGCAACGCAATTAATGTGAGTTAGCTCACTCATTAGGCACCCCAGGCTTTACACTTTATGCTTCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTTGCATGCAGGCCTCTGCAGTCGACGGGCCCGGGATCCatgagctgcaacggaggctcccacccgcggatcaacactctgggccgcatgatccgcgccgagtctggcccggacctgcgctacgaggtgaccagcggcggcgggggcaccagcaggatgtactattctcggcgcggcgtgatcaccgaccagaactcggacggctactgtcaaaccggcacgatgtccaggcaccagaaccagaacaccatccaggagctgctgcagaactgctccgactgcttgatgcgagcagagctcatcgtgcagcctgaattgaagtatggagatggaatacaactgactcggagtcgagaattggatgagtgttttgcccaggccaatgaccaaatggaaatcctcgacagcttgatcagagagatgcggcagatgggccagccctgtgatgcttaccagaaaaggcttcttcagctccaagagcaaatgcgagccctttataaagccatcagtgtccctcgagtccgcagggccagctccaagggtggtggaggctacacttgtcagagtggctctggctgggatgagttcaccaaacatgtcaccagtgaatgtttggggtggatgaggcagcaaagggcggagatggacatggtggcctggggtgtggacctggcctcagtggagcagcacattaacagccaccggggcatccacaactccatcggcgactatcgctggcagctggacaaaatcaaagccgacctgcgcgagaaatctgcgatctaccagttggaggaggagtatgaaaacctgctgaaagcgtcctttgagaggatggatcacctgcgacagctgcagaacatcattcaggccacgtccagggagatcatgtggatcaatgactgcgaggaggaggagctgctgtacgactggagcgacaagaacaccaacatcgctcagaaacaggaggccttctccatacgcatgagtcaactggaagttaaagaaaaagagctcaataagctgaaacaagaaagtgaccaacttgtcctcaatcagcatccagcttcagacaaaattgaggcctatatggacactctgcagacgcagtggagttggattcttcagatcaccaagtgcattgatgttcatctgaaagaaaatgctgcctactttcagttttttgaagaggcgcagtctactgaagcatacctgaaggggctccaggactccatcaggaagaagtacccctgcgacaagaacatgcccctgcagcacctgctggaacagatcaaggagctggagaaagaacgagagaaaatccttgaatacaagcgtcaggtgcagaacttggtaaacaagtctaagaagattgtacagctgaagcctcgtaacccagactacagaagcaataaacccattattctcagagctctctgtgactacaaacaagatcagaaaatcgtgcataagggggatgagtgtatcctgaaggacaacaacgagcgcagcaagtggtacgtgacgggcccgggaggcgttgacatgcttgttccctctgtggggctgatcatccctcctccgaacccactggccgtggacctctcttgcaagattgagcagtactacgaagccatcttggctctgtggaaccagctctacatcaacatgaagagcctggtgtcctggcactactgcatgattgacatagagaagatcagggccatgacaatcgccaagctgaaaacaatgcggcaggaagattacatgaagacgatagccgaccttgagttacattaccaagagttcatcagaaatagccaaggctcagagatgtttggagatgatgacaagcggaaaatacagtctcagttcaccgatgcccagaagcattaccagaccctggtcattcagctccctggctatccccagcaccagacagtgaccacaactgaaatcactcatcatggaacctgccaagatgtcaaccataataaagtaattgaaaccaacagagaaaatgacaagcaagaaacatggatgctgatggagctgcagaagattcgcaggcagatagagcactgcgagggcaggatgactctcaaaaacctccctctagcagaccagggatcttctcaccacatcacagtgaaaattaacgagcttaagagtgtgcagaatgattcacaagcaattgctgaggttctcaaccagcttaaagatatgcttgccaacttcagaggttctgaaaagtactgctatttacagaatgaagtatttggactatttcagaaactggaaaatatcaatggtgttacagatggctacttaaatagcttatgcacagtaagggcactgctccaggctattctccaaacagaagacatgttaaaggtttatgaagccaggctcactgaggaggaaactgtctgcctggacctggataaagtggaagcttaccgctgtggactgaagaaaataaaaaatgacttgaacttgaagaagtcgttgttggccactatgaagacagaactacagaaagcccagcagatccactctcagacttcacagcagtatccactttatgatctggacttgggcaagttcggtgaaaaagtcacacagctgacagaccgctggcaaaggatagataaacagatcgactttaggttatgggacctggagaaacaaatcaagcaattgaggaattatcgtgataactatcaggctttctgcaagtggctctatgatgctaaacgccgccaggattccttagaatccatgaaatttggagattccaacacagtcatgcggtttttgaatgagcagaagaacttgcacagtgaaatatctggcaaacgagacaaatcagaggaagtacaaaaaattgctgaactttgcgccaattcaattaaggattatgagctccagctggcctcatacacctcaggactggaaactctgctgaacatacctatcaagaggaccatgattcagtccccttctggggtgattctgcaagaggctgcagatgttcatgctcggtacattgaactacttacaagatctggagactattacaggttcttaagtgagatgctgaagagtttggaagatctgaagctgaaaaataccaagatcgaagttttggaagaggagctcagactggcccgagatgccaactcggaaaactgtaataagaacaaattcctggatcagaacctgcagaaataccaggcagagtgttcccagttcaaagcgaagcttgcgagcctggaggagctgaagagacaggctgagctggatgggaagtcggctaagcaaaatctagacaagtgctacggccaaataaaagaactcaatgagaagatcacccgactgacttatgagattgaagatgaaaagagaagaagaaaatctgtggaagacagatttgaccaacagaagaatgactatgaccaactgcagaaagcaaggcaatgtgaaaaggagaaccttggttggcagaaattagagtctgagaaagccatcaaggagaaggagtacgagattgaaaggttgagggttctactgcaggaagaaggcacccggaagagagaatatgaaaatgagctggcaaaggcatctaataggattcaggaatcaaagaatcagtgtactcaggtggtacaggaaagagagagccttctggtgaaaatcaaagtcctggagcaagacaaggcaaggctgcagaggctggaggatgagctgaatcgtgcaaaatcaactctagaggcagaaaccagggtgaaacagcgcctggagtgtgagaaacagcaaattcagaatgacctgaatcagtggaagactcaatattcccgcaaggaggaggctattaggaagatagaatcggaaagagaaaagagtgagagagagaagaacagtcttaggagtgagatcgaaagactccaagcagagatcaagagaattgaagagaggtgcaggcgtaagctggaggattctaccagggagacacagtcacagttagaaacagaacgctcccgatatcagagggagattgataaactcagacagcgcccatatgggtcccatcgagagacccagactgagtgtgagtggaccgttgacacctccaagctggtgtttgatgggctgaggaagaaggtgacagcaatgcagctctatgagtgtcagctgatcgacaaaacaaccttggacaaactattgaaggggaagaagtcagtggaagaagttgcttctgaaatccagccattccttcggggtgcaggatctatcgctggagcatctgcttctcctaaggaaaaatactctttggtagaggccaagagaaagaaattaatcagcccagaatccacagtcatgcttctggaggcccaggcagctacaggtggtataattgatccccatcggaatgagaagctgactgtcgacagtgccatagctcgggacctcattgacttcgatgaccgtcagcagatatatgcagcagaaaaagctatcactggttttgatgatccattttcaggcaagacagtatctgtttcagaagccatcaagaaaaatttgattgatagagaaaccggaatgcgcctgctggaagcccagattgcttcagggggtgtagtagaccctgtgaacagtgtctttttgccaaaagatgtcgccttggcccgggggctgattgatagagatttgtatcgatccctgaatgatccccgagatagtcagaaaaactttgtggatccagtcaccaaaaagaaggtcagttacgtgcagctgaaggaacggtgcagaatcgaaccacatactggtctgctcttgctttcagtacagaagagaagcatgtccttccaaggaatcagacaacctgtgaccgtcactgagctagtagattctggtatattgagaccgtccactgtcaatgaactggaatctggtcagatttcttatgacgaggttggtgagagaattaaggacttcctccagggttcaagctgcatagcaggcatatacaatgagaccacaaaacagaagcttggcatttatgaggccatgaaaattggcttagtccgacctggtactgctctggagttgctggaagcccaagcagctactggctttatagtggatcctgttagcaacttgaggttaccagtggaggaagcctacaagagaggtctggtgggcattgagttcaaagagaagctcctgtctgcagaacgagctgtcactgggtataatgatcctgaaacaggaaacatcatctctttgttccaagccatgaataaggaactcatcgaaaagggccacggtattcgcttattagaagcacagatcgcaaccggggggatcattgacccaaaggagagccatcgtttaccagttgacatagcatataagaggggctatttcaatgaggaactcagtgagattctctcagatccaagtgatgataccaaaggattttttgaccccaacactgaagaaaatcttacctatctgcaactaaaagaaagatgcattaaggatgaggaaacagggctctgtcttctgcctctgaaagaaaagaagaaacaggtgcagacatcacaaaagaataccctcaggaagcgtagagtggtcatagttgacccagaaaccaataaagaaatgtctgttcaggaggcctacaagaagggcctaattgattatgaaaccttcaaagaactgtgtgagcaggaatgtgaatgggaagaaataaccatcacgggatcagatggctccaccagggtggtcctggtagatagaaagacaggcagtcagtatgatattcaagatgctattgacaagggccttgttgacaggaagttctttgatcagtaccgatccggcagcctcagcctcactcaatttgctgacatgatctccttgaaaaatggtgtcggcaccagcagcagcatgggcagtggtgtcagcgatgatgtttttagcagctcccgacatgaatcagtaagtaagatttccaccatatccagcgtcaggaatttaaccataaggagcagctctttttcagacaccctggaagaatcgagccccattgcagccatctttgacacagaaaacctggagaaaatctccattacagaaggtatagagcggggcatcgttgacagcatcacgggtcagaggcttctggaggctcaggcctgcacaggtggcatcatccacccaaccacgggccagaagctgtcacttcaggacgcagtctcccagggtgtgattgaccaagacatggccaccaggctgaagcctgctcagaaagccttcataggcttcgagggtgtgaagggaaagaagaagatgtcagcagcagaggcagtgaaagaaaaatggctcccgtatgaggctggccagcgcttcctggagttccagtacctcacgggaggtcttgttgacccggaagtgcatgggaggataagcaccgaagaagccatccggaaggggttcatagatggccgcgccgcacagaggctgcaagacaccagcagctatgccaaaatcctgacctgccccaaaaccaaattaaaaatatcctataaggatgccataaatcgctccatggtagaagatatcactgggctgcgccttctggaagccgcctccgtgtcgtccaagggcttacccagcccttacaacatgtcttcggctccggggtcccgctccggctcccgctcgggatctcgctccggatctcgctccgggtcccgcagtgggtcccggagaggaagctttgacgccacagggaattcttcctactcttattcctactcatttagcagtagttctattgggcactagGCTCGAATTCACTGGCCGTCGTTTTACAACGTCGTGACTGGGAAAACCCTGGCGTTACCCAACTTAATCGCCTTGCAGCACATCCCCCTTTCGCCAGCTGGCGTAATAGCGAAGAGGCCCGCACCGATCGCCCTTCCCAACAGTTGCGCAGCCTGAATGGCGAATGGCGCCTGATGCGGTATTTTCTCCTTACGCATCTGTGCGGTATTTCACACCGCATATGGTGCACTCTCAGTACAATCTGCTCTGATGCCGCATAGTTAAGCCAGCCCCGACACCCGCCAACACCCGCTGACGCGCCCTGACGGGCTTGTCTGCTCCCGGCATCCGCTTACAGACAAGCTGTGACCGTCTCCGGGAGCTGCATGTGTCAGAGGTTTTCACCGTCATCACCGAAACGCGCGA  P;   $         #   B   D   .      &               0   1   +   =   H   &   ;   d   c   *   -   6   #   $   9      5   !   +   (   0                                    &                     P   )   "      I      (   4      1   -      #   H      6   H   y   D   *   0      "      $   ;   D   +   3   m       ;   @   R   9   3   +   #   !   '      2   /   $   %   I      #      %         &                8   #   (               D   /          3      "   !       >             L   #   /   @   J   4   5                   4   0                              "                %            <                  !   %      7         -   )                  L   (       %   6               )   !   "                                                #   B   `   7   H   ;   /      -   )         (          "   +   O   >       =      
   !      #      "   +      .   #   '               A   5   $      8      $                       $ T ’“¬Ù¶·	J	K	#O|~}~×{BtØÙ±²³ëÊ !"ó" U ”¯Úq«¸Ýþ
-¹/§c�C.´2Eˆ!å!"#N#®#ë$ 9E’Û“×Ø
$P|§…°uÚKBYà =!!""ô"$#0##  Ä­
&×	L	l
Ë
7}³Øuäëâò‰ìtý– Ë !©"Ï"~#¹$B lw¶:ƒÛ+rž¬ð»	

ß
;eÔ×Ú.ILO`‚ÌÒºì½.6£ºˆ‹]Š�8V•Ô×Ud‘ˆá±öÅîd ª ï Ó!æ!"7#ì$D V b À °˜¹ÆÌ�Ÿ
E
 ’À-šüm¶1OMöGã
.¨´Âó¾âïùDQœ
·ÅÈºùWzûm·'3¤U } ‰!÷!"·"<#O#¯#. T•6@ëeÇõu�Þ 	W	$
ÿ
(ý9€³éFŠ I£ìYX|UØµ&gF"„"## oMà|+	‚	AV¤ ‡’û¥@_Ü0BdÒ3/?.!& G :‰
l:	Ù
Ü
%GQùLÃì}&†Eè vôÛ„1šZî !>!€!e$ a®›¶ ;�ˆÃ© «÷ò¦C�cÀ ™"8$R$ " 7 FóoÜØ5V~)¹Çg¡¨i-Lì#"þ$ Ó“”-±j›	Ä]á é!õ"%#1# ©=ÆûyD	G	f	k	8�c½K¹#ê#%$,$0 J ô Åï$â�
'SM	•	¢	e
.~�T–ÑåìãâaPk»ÛáDzê~^s¾ô Ì !£!#É$1 gkB¹\qó†	‰
â
ô
ú
€Ù%Ý=Ïø$cqŒš¯IRÚó—ÍíuOè ò Z!w!´!Á!>"ª"Ð"í" #†#º$+  S^®x*<GõÇØ	&	6
m
Ì
J\"…÷´õvŽ2Ë±äŠŠñþ—ø !R!Å!."”#ú#= m;©Äñ8	à
,ÕØûGJMƒõa»âT|,/KôbŠ‰¥PWxÕØCVŽ÷¯â+ˆê÷éùkïæ ð }!¡!¿!ç!"<":#ø#ü$H — m(ÑCZsŸ

\
^
<½ù/ÓÝßkãí›7¤é»Ò!”àø	^|‹—ÆÈœôÿ/7Ae’º¼·¯!?µú46j!Æ« 8#& Ä Ê Ao÷DÜš‹¸A 	
(
Â
ð
Û—„¹È5Ýev‘–ûÈÎ²ÀÔ!; �Êx·Ò„Œª$L,S¡­ì�¯ÀÐ-‰æ¼	Þ	ã	š
¤
fPa°ÍRœF¾Ù-Ä'‚ŒžÖ9]‰ã7È"e † Æ í$d Á .|tÀo8nÇÍú	¡^p{“–#:�Cm›¦ÆœPd‚—É÷Úäìy‘©âþ0�µ¸Ã¿ã>úý?EHRU“Æg|²·x»ú#Ÿ;‘¸ú4¥~ ½ !^!…!Ž!‘!ø!"""�"¸"=#õ#c  W º 	ó»\uº  F
„
¿áì|ª¾Å?CÕán‹Òý^‘�¬#„°·2g¦ï9œÙHò/XHXo~�Ð)~‰žðö wa�¹½Zž±I�QX„>YnˆŒ”Ôà7kç¢ ­ j!Š!©!­!°#%* ê*¼‚õ	

ë>˜N”À3Êôüb­¶ê9Í¸4ŠÉ8t¬(.0 V � P#‹#!$($- c O±ï†0>™§|	©	¯	Ç	j¨ÁÙÿì.nyžÌ	S¨=O×`
}ì€�3{ü6 (�à7³ìüX	š	Ù	
%
`
i
y
 )>þ4�åïòy´ºêÌy“Ô#¤Zï?o]hLˆ  ”!+"…"3$$#  . ¥ HAz|SÉëöEv”Ž¬ÕiGXæ‡˜M«Ag" "$ EIómù±
ažÉB‹¦!k€ú#™íY”§Î#ì'> C!9 1Ufh–¨ýfrÀÈÓß		p	W
È1:$ÆiÝp²×µçþJå1!} r-8VÙK§¶G¯¹Þ##$   @ ¾ÏÖèÔƒ	°©(/!E#¬$¶$5 ™  bØù}O
B¥eì£“Ãe|õN£š ë–¿?g¢Ú%4ƒÏÛ o‘ Ù+ u œ Õ M!F"˜$×$! î2áçÑ	
“A\ˆ3]í¦`t¾Ý"C½íñ7Â$Ä9@ª#+ pN+‡²4««,	=	w	=
W´Ëü³'TA1e(=±¾Ó0BäÙül¡½/ÎG!ò!`"á$( H C§�·ÄsÚ
Ý
ò
&HTc7§Õù+M]o¼ÐOõSÖôÂ[
 !.#0  FÖŠm˜Qú�¾+?‡;	n	w
É[®R!íV×~ÐV'‡šýÌê×2 ,A!ƒ!§!¨#ß$ Û iÑ}*
¹
R†M7Äg˜ÊéÜñï ?!�!Ä"ö$ \ ;4ì	-úu9ÄgFw"t…›û!N$f$ çÈ¸kq�¬Þáé½dš"s# "b$œ·!å<‰+‹ç6N6 : í# ‹ Æ Ì ¯¹œÃ‚Ä}vý	ÝˆŸÊø‡(óD‘{Á »!9$S$ ù[	X™ª‰ú¡“­§´Ü!q$ 6ô¬øGÝòzÑÀˆ‹h¢×X.´ØË�Ò ï!$ # GËt°ïcC¤»Æ*soßí¼#Š$ 8 o qƒp1œÙ,
Wèºßëj�Ð ›#ÿ$ �¢`6W7ÌÊWè–Èip©Mhé¨Ö!$"v# Ý ÔÎ•ÔðÑ
…¬ñÆ"˜#¥#& ) C Þ'®º�	ì
™õ.|õ²mKÖFE\kÝ<Åw Q â %!—!ø$% ”Ó"	i8xóœ
,{å5!ê!ç"¿$å$ Ï�	»
Ä
ò(ÔOq3²¾ �^É"ö"&#2# ` ò _¬Q>™z�(Ê$‹þB	E	H	i	c
9”ú·È 6$P$ Ç.¶ÂÜ	¢
‘»Æ
Ec¡àw€ ó#&$% ÔŽ¬ãOîaðl	ðó¾L»O º#ë# ^ ªûXáNü`£±Òî/	1	g	¹dž�¦¼Ê!2"®"$-$¯$%P 1J¤IPþ�¡³(ÄÎT	Ä	à	î	f
È
/hž	f´ü —ÃÎÒæ;¯ÇÆ�UbEl±M{,HyëJTWv‡[Ä0�$t¿ûþ " g � 2!›!ž!¤!M"+#p#Ñ#$) ÆÌêðý%ãó#Ý16ëœ
2=£¨KäEkã†µLQÜ;Ei¤Ðã«OB"" õ ÚÀ	“ß/sw]â‹ºV_€á` Í Ù !ý!H$_$…$Ê$ò$ K =’‰§�¥TN	–	£	k·UHÛâíÒ¼¢õý "7"€#Ô#ÿ#h$I +6¹hlwìº½	D‘è¾	Á	û
š¡éRU»I½Ï Úˆ·ÀQZý/P�×ïŽ› ØJS_Råô…ÂyS·9Ö"![!Â!?"«"ç#©$Ü$ï$ ¢z&§U¦3	‡	ã
>ŽÐù|°ÆÛî`åÇî‹P"( ¬ �ïC'g¯]k¼Õ	S
|
Š
æÈ/bnÜSd|[‘ÛÒ¦{˜Î—é x!Ì!Ñ"@#»$Ð$4 ‘ 
Z¢ÿOšGrôÌ	å	“
Ñ
õ
w²�T&4Þ6ò%r)œ�* ¬&vP% j ó e!µ!’"î"û"####‡#z$Ã$ Á×†nž¤ö		±ö°ƒ/"4"»"•#‚$1 9TÃ¯yÀbÞ·7
n
²
Í
v#wƒØtr �†&Ì‚i²$–û‹o‹Ê“ !S!Æ!"U"ˆ"H#ã#�$Ÿ$- 	  ü £ã•¿+=H…äÈñ	K]†øL&H<3„‘¾ý‚òÿ˜ÂÈù a!n!°"¾"Ì#$/$ à w_»"ÔÙ'	1
r
¦
®µª¨ÈåÉ¾ˆ e"Ú"û#$“$±$#  p’ªµÊ
×
6,}|tã
ê¦„b�A×JˆêsüX•<!~!‡! "Î"M#H ¿ nvLdÆ�ÅžV	º	ÖÙüHKN�†‘Ë‘™è-0L‰õAcŠ\‰�³ëòXÓÖáWø{›~Ç>øVyÄú%fl¶í&£T c -!"ƒ";# ! F 	k:€9	øU}(Æ 
Dÿói,ë™¿ !è!ý$6 <áwúxR[Æò¡	5
ˆ
á
-!„öb¼ÜÐ÷#b‹`™OºàCHQyÙJ°ãé}]‰ðrç ñ ÷ Y!v!¢!À!="…#ù#H Ã nÉ'#K Ïâ	[
]
™
ï
ú¯`ÞQEjÇâšØ4{óa‰Üd“uÅÇOwóú .6@B�»®¶® ´5 Çè¿Å å  !;"9#÷#û$y ~é)º…[t{	¨	®	Æ	
ƒ
¾i{©ÄB•§ÔØàþ9mlÑœ«Å=—¯f��¥8“ÈË<NWÖá
/2G_n}Œ·Éû}�¬éõ	8v|üGT¸¼ÌY’�°Hf‰±¶7w"2ž=X‹�“«Óßù6j€ ¡ ¬ ¼ !i!�!�!¬!"œ"D '0e²üDq¿ÒRD
_
h
=0#Åh	o�äîxÈÔhË±¥’´Óæý"äù "˜å0“LÍ"@ë¦\Kf‡= “!*"Ÿ"* ? ˜ 1ø*±çë2¨&M
™½ê¼•¾>Á#f¡½Ã‚ãÎûkŸnt L!E"Ö$0 B3Eh¶ÃŒ½*)
¸
ñ
bÈ,…¦Q 6LnÖÏfÃ—»üÉÏN!ðÕóÁ	 ¦!ú!-# Å Ë !ø#ü	Ü˜ŠˆžæÉù’†à¬èz³5 9 Û!r#p$" 5pœFÊ0›sîBÐ£VºÉçÞorWn³×Ê§Õ!u#$‰$ ÝÍÎ¹Ð!	
Ã
˜h„ô±p«w2lJÕD[œv4!$ ^Ó�«M -N_Œ¢í°µÁÉÑ#.ŠA	ïbò�ùvŽ¥º N Ç É!ò#; ‘Ëé¦H�"S	ß	›
1gjÞr¶<¢G§ÚJ®ÆDÅ´K:£+ŠIV¹ZÃâ¡à#úý  ! f Ø š!�!
"L"o#Ó#D y¸%&T®�F¥»ç½	ä	R
’
Ð
 Q±ºåÎS3‡5¿.aÛRü(.î{�Ÿ×^Qäí)_xäRzÆ%8$ i !!O"?#æ#Û$î$+ Â…ºm!£ð	q
¥
±
u°%G¯×©ƒ�hÇ•È½ünÉÁÇ‡ ’ `!m!"º"Ù"$Ž$’$3  ¾ ucÅ9ùow‡
Ö
5|Ê{�ÛéN[ˆŽŸ¹ßBGÒþ@šh}Æ=x‡Ã$eû”b ¾ †!"‚"Í"m Â &/d}È&p¾"„æÎ˜
h¨®ÃA_”¦×gDnœ§ÆwªÇ3g	e€˜Ê`ˆ³Ûåü;’Õãÿ1¶Äú=Àäòù"5?ûFSµ»�œ e³ç<W[Š�’ªÞø5m†<  K!Œ!�!’!«!"D"ž"ö#   ›E/Ìû	¢Ç+—¥‰‡�KƒæómøÎªÂ1IV¦8 ù!; Á¹^‹È"º°
¯î¹qñ$;†ø¦IQ¨Cíuz³J€*Pã^”Ç¸Qy¼Âû$m ¹ !_!l!	""¹">#�$Ú$@  ½ %šDb½Ä]v!†
¯
4®í§­Æ@Öˆf†J§òtÔIZžÞù0ñø!º]ÿd†Â#VZ‰Ž©Ýlk!‹!ª!R » ¼ $
Na‹¼ùúûü…
¨â«¬ïDâoŒþžôõ$…¸hmnoðñþÿ óô0·ÓYÑ*k÷(žŸ[\Ÿ þJKbcr‘…?U�¨èé£ ® ®!¯!X"j"u"v"±#9 X { … ¨ }ôŒYA
G
ž
©ÀðEãpÓÿ_Ÿ%¹×ip>�ÚîõAY¸ÏpÒ+l¦b ¾¡’@á8ê¯ °!Y"p"w"�"3 ËÿOõý»ß¡�	ã}¿Bc�’­ö±3:åI1ŠŸx›)7²LsRYo•Õ¤ k"²#%+ & 4 Y © Šë½ì<:
B
Ÿ
>F‘ ?™ÀqÁÝ4SÓ®	¹5
gHöâ)/ë±!"$)$# 1 | † œ ± ´ .õZØ	
¶ì?Ô …ºØjÛö8ZÐËèÇ¡u­Ú9x"ï#! +*\8ƒ”ö	 
ñ�&MGOžBq§:¿ü¢9“ÑW q"Q#Œ#' ~�çªH
ªÁÚäq`?•ï¹õý,cm·ëcÃÎ‹ÊA1 ‚ ° Z"Ž"È#u$ €eÌõð•1¼%¨3íÚ™*€æ~�4¢#%2 Ò [K�ò'öš‘¢	°	rkq~À©Â	d–>Ž—®;¬T>,‹ y*ítSZ5p–â"$¢$/ PÎWž å#P,>‡?}	È	
‡œÏ Zu²4zŸ[Í
J©)2ØAqœ8Må|ýQÃ#$ d Ÿ >}²þyà‘	ª	ä-Cí/o“÷]Pa€-³�Ò­Ö<\ ¥ !l"³#% 5 �í8´éÿ	
C
j
?Eÿþk±»ÁÍ-¥®ð0Mì P!²!ÿ!,"—"#$*$c$I , • È ‹ŽìB¾í…X©¯ä	&
;
*ß?•‚A_z¤ðó¡ë@šr•ÕwšÂ%iÞö5;ÎÔ[¯@p6&h†ŽIr÷i}Ü . ½! ' Z ‰ ¥šU=xY	›	55æz”T¼ã* •!å"ô$# ª )/áýiÂÚ	a
z
 
G¬Æ’µlàzµšÕ$
ÙRº^‰S"†"4$€$  /öìÌh­ÕÖÙéç'¬BXÓÞÈhÃ t!("ð#‡$% / 2 � ¦ ² <IB{}Ê÷w�­
·@yƒ†HkY9Ñ™úFvåÛ:` "€"‹" ‡ µ 9;üj»ÜÌÈˆ¬NPõaã€H y"¡"a$  } ÜÆ=T[›F•Ù

�uí8W÷[¢–c®& · »t¡F„÷	!
ò1bŽNH¥ûš;•<ý6¨Ï÷”ºŽ� D!{# ±,+þ9O²oHŸÀ 'P"ÁrÞÀ:›b· r"  k s Õ ÷ JV]ô•‘¡ªŸ$w£$‚ñ(Ò? X k#;$U$  � Î æ ãnú`	K1ÊCüŒ§l�Cî¨ÊZlí“‚R#a#�# Li©Åþé	�—tr€Sÿdì·"‚*Œ�¨Íƒ Ï �"É#$8 2—žÁ	q	X
µ
«2;Û%ŽÇjÞ;qÎah½@_ð]Kæ…öþ-n¸2ŠÄc™Ë]·£@H°2 Û !£"%# VÎg€ÉèÆÂÉ; ØÞ¶èºä~�‰`BKß– ± ##J$v$( � g´sŽÔ«„fà	¶	I
�áåŠáA³Ì–dÏs.9WÚLºJ !"["{"Ø#Ì$ ×3Õî„	±É‚ŽCÞ !ã!·$  ?fÍÐÞÔñé2§©6	˜	ZÛšª+ç•)5 A �ö–&¬r£#  ¿e½&Û4µ‘�0!F#F$­$%D \!úL~›œ£P
sÃ7O˜•Éä›£Äú¯ÔÄ— -Œ¡jpz£Óñ„î¯uT¤q—p¡Ÿ º Ö ÿ 9"K#$Ô$/ š c‹ó(÷’
…¦fÁí¤ï
ae”—}�öX¤G<ìü±?À@&+5Ðep¦ö’à" #s$Ø$   Ó JŽ™SCmrªÄ9?f¢¾¯U£”[Ü¡Ú, N!ã"Ö# ÞLÙÒ9bš	±	æ
lø­:hÛ6v � G"Z$™$£$3 QN3©$§?]@Š	É	Ò	
B]�mòZ[Ý‹³ï)5aD3îB®Åf˜à©Ê?8¦"‘#«# àæ]	”4^W§’ \ª¾89R‚#" M ”ïX\R?Qèdè
ÐPvÓu{¿ÐÞ#Î­ò:NAæ(!Ä#! ÏûŸ5-ˆâK	~	
ˆ‰dî·K*ÙrÃ%�¤}þÍ[#g#j$  q~³’Øò;z‚—¬át	’	yWÔC´Úý®¶"$\$â$%%> ÿ?ÈÛO,ˆÿ)V|³¬>	P	x	¥	«	³	>
€
	ÍnÌ(0Ã#JU€”^fù])>�__‘mðÔ ×=U÷E ] !H!V!I"m"  �5Há-	Xµåw¹ý´pøB2<YQb²Ý.1Ó¢G¦ Þ!a" e   ³Vú›.Dî(é¾¿å¾0°Ïx !ó!Õ"´#¿#›$¥$ 8D‘®‘«	k
ý
"NÖá.z¦¯ñA1  "¨"/#}#­#L S59‚êß*t€ 

#
D
Þ
'@Ud£Ó 8_Ÿÿ¿Ñú,ël²¼¤µ?EN^Û5¢F¹â	H‡¢7U”½TÑ2P‡àÄT°¹×õ| © î Ò!¶"# 6 ònµÂÛ
F¨K,Âf%çªöhšñ0¥Ã\bí ˜"d$/ I ¨î
jA¸Å;Fô	%	ó
ù
I[œô$S<Î�
pá1jÚ~–ÌN!Q!³!Ä!-"“#¸#é#$$+$@ – É l�öC‹™©ÐBRYëŠŽ¿,@ˆå'
+ø–ôƒ¸S+JÃ&Ñ�ß÷{¤Õ\›þÇÍöâù3i‡éøj!¾!J ¹ -»¿înô	ù	àë½>]ozê"ŽBŠ¥]�"ƒ›cx~–î›¿ØR§Ùëñ�ýWœÏ(aˆµ=>`ë3{�Ps:‡-æ/ ]!„!¨! $4  - ¤ ŒG§yH{ûl“°	o	Ø	V
x
3Ü`ñ¹AÖWxj—î ÿnq¦ª7J~®Ý B!2$~$5 ½ía×†æª<	
<
@Ê\¯Âd{ôS¢ìsÿð'6<°Ù8AØ'¼Ú.Í�ŸØ› Ô F!ñ!_"D#©#«$µ$à$ [ ¦ùr>|~†v
S6ZÔ*8\U™ËéRÖ+@!‚!M$Þ$õ$ Š ›æjŒZ	W‡5Ý' n _¯Vy+
6ËçÅŠ•hêŒÞgèœ î!  ( Ü &ÒÓŒ	œ	º
ë
ÓN{7ò½+;zäð $!–!Å"æ"¾$÷$ ] ñ PúWà`0	Û	b
¡
¸Å	D “ß¶»­"$5$O$4 <0ˆI£ò¿ÃÍêÃ	í	.³ûv\Â:ájÑ…�TD°LhGxSu†U/N_œ� ü ü!A"Ð#g$ñ$0 « 	*¡5vëî¦¼þCNjÀ	Ë	Ô	{
èTH¼Ç¶Pm�ñ{O›ÖÅZ�ÚÁÑŸ¥«¶ŠÕd!y$Â$ û 8â¿0
K­sq;%#ú�T"d"‡"�$   jvQ'êàu!„# > 0÷C¹i×’½tvèu­­âê�¾eiÄ )"›" ÉgríÍßCç›ÔÉt#ˆ$ èlŽE®ÖÚ(Yáß  n#ñ# c%¸ËøŠ¸z2èÍ:²O™<wæd7 ; a "�"Œ$ z § #™C|M`®
¦A‡eÖIl~ÒšTÜt"Œ" % 0 3 ³ -[~æ© ;„Œ7çÂûGÇ#î# ž =J|�"”=x�q,)Z;[ " ˆ Ç ¤.èWhw¨þ	Þýkß”Ô,v$õ:Í­Q%…
|¼!R"b$  :<Ë¬
ûùOôbÒEäÂ "   j r ¶ Í å °ºâs~_	J� ©ûÀÉÝ;ö’šð��`#z#:$T$ Œ ³�ÄÍƒÅe–‰@¼ËR^Ý\‰�bˆ)JI z"¢"  2Ú´5	Y�«È”qE$% ~ IÝÑ˜8Ka
å
î6`8¡½”È¢û9¢°Ãð®d õ¹ ß"Ÿ#r$Ó$ ú[4>\\	‰	OlYŠÒ¬­£—¨ÉZ#f# Ç(Uœ²×ñG�–
ÌvšÂ"VXø\^ïÓF¯µÝ!Ô"¾# 7ñ­Þ)ó"
!Ò#ê£Œà¡áei1©/}•|#< ¸ k¼õ¦GzÏê‰×	ø	U
÷ó2\éÁc·�w}I¾¦ü&›£<–Øí=þ7m¥©øè»Ù-Ì�ž­åš Ó E!ð!C# m ø{…ê
ÒÊ‰&Qf›í!½$ ð ú ‡ùHu¢ñBM¾/
OpÐ~YÐù¤µÔŽ Ï#$ = BuDP&‘sßtšàœ m# $ ˜,LZ_“ÿ:p¥(1dÕÌÁ;cZ s"Æ#‹$  q ä ²-rÌÊdg«
IÞÓ+Q#ô$„Ñ™	_#! HZ3±Öð1€`³~
 ¼Á!“ÇU¯ÂpîÒE¸ Ó"Þ"ž#½#D$Ò$% l ï ù †y÷ALˆ.
 ö[é¢ ½à%ì¨l¤ø%Pe,¬Ó™ B#  p —q2AKY^É0_fª
’Ò%ƒÐÑ Y l#�#7   O t u ì í î ø r„–ƒ„…WXwx�ØÙÚÛ12õö./@K-
XYZ»¼kxö÷)*+  n o œ#<$ % 9 P v Ö s…žÜ3Ú[–R«fyŽ¨ ò@ p ß#=$V$% Q tŸÛËéq<”z!ê"à#- ‚ ® Ï SE�û—�
è 8SË2Dx¬Ám—qï©z�Ô©Nóêƒq *!q!%"Ž#W$%) : w žä^TÌÝadXoa	Œ
‰LX€ýgw‚Éª"[]“Ýî!	~©ë ³"S#w#>$ × ç ÿ †c£4i±7\mÍ�¨DjËmÂCiA Î!×!V#b#$ R Ñj\–Õd	€	
Žêž,­ír,òë"	# MñÒ
M
À
  ¸#=+�‚„ {!‰#  ªÆ Ïtê	)s†TeÎÐ Ç"™#¦# Þ uÕ¡—ÿ Üœ˜u�Ìƒ•©�"##Ê#á#$L D 3çß(¯F»Y
�
¶
í
`yÜé!T�öOkrÏà	3y­»`ñ?nLðÿª¹‹ŸLÅG{�ÕFlªÌ ´ëIx±Å 3 R r ã õ +!g!˜!n$ù$( ƒ ¯ Ð YÂ ‚ä	Ž	¬<š´ØÈ<}ò[¾A^rÛ†÷.oÅ3šOô„Ï  * “ ˜Ÿ7TƒüMç	39ßÌ/fi³6˜×4^¸Æ	!r!&"i#	%% ýQI˜r	&bE'Âöçnd]Þ=¤AËÜ &!á!¤"�#X$%%6 Ÿ_U€ÞéŠ¤äpË
	#	÷
Ã<XÒ(�9ÙhßMxƒ·éy#^ŽÞŠ�ï®-Lx…æì ´"K$w$|$À$ x ÏheÊj6ÿt»«åt\x# ; ÊÍ/bÔÇY�
!Ê¦ô¢"cC|ªl — ë!è"T#]# Wå•�çb	ŠMV ðYþ¹”a
à² 6!##?$l$æ$ Ž Ø d5…n	Î	Å
éž»"Á"ð"ý"#!#Í$è$) ‡¤²áž	·	•
Ó
‚Š)Œâƒ‹ô ´Í—©+'àeÐtXÃGjRB K ´ !Ø!”"Ê"!  htÕ¬Ð8]J
óÕæ‹æPŽE4n–¿DÛ(M_âÏ!\"|"W#c#A$" è µ ¿�jgéö¼
Îâ8BûrkÌƒ³/:' 8!·!÷"#'#3#Ù#$Å$ S ÃØÚÖ%ÖÜI	{²¸s-°DÉ ß !ä!ò"
###¸$ê$ a kµ?ô{—ËŒïÿ*	�	
:û-Áî	¶ö!"#6# `­Òˆš‡4ë¸Ÿƒ�7$Q$ ó R#]fŽ)pC	F	e	j	…	”	d
�•®Ê½óì"ÿ"È$ @Ñ¨®·Ã	7	Ý	
£
Á
¼FÜ›á,è �–¹>*6… |!  N{sò7/=m¦ëxŽƒ"Š#ô#'$% gßÈêòø™	Ç«†>,¸ $ ÎÕ3ªÓv	Ð	N
’³[d¢²!ì$ * —$  Ú Õ�—ÐPm	ë	t­øUfsÃ"§# ¸ÂÇ·äp|u*M¼º!ì# ‚«÷¡bñ¿‡ÖÏÑ š#»# B ­ïñ'ôEÜÿP È"—#¤#ä$% _ «˜â'íïý	h	º1"®$%% ÙüOý¤ ²Ü05	Ç
’eŸÍÏª1!6"*#þ#$G$^$„$ � €Y ¡f™2	™vY€„–Ë!‘"ú"###¨$Ï$#  ß vÀÖ¢”a¾Ý„�Óã¶	‚‚…�§½3"¯"½"G#Ë#â#$.$ž$°$B E Kà‘œ´Z�ÅU	 	¹	4
É
 +€…�÷s˜Ïç	ö"aˆ@Å_˜²ñ	ƒIazèò|ÖI\Ur˜µì%Wq¢S ö  !,!;!X!L#` è±û)°JQz	§	­	Å	á	Z
g
‚
î
zê
"Äý18PlÐá%L™ÄÓ<z–®Êœ¤°¼Çò‘MVc!.FmN|«-{Œ ÂËKX‘ÌGˆ°Ív1¥žÒJs   » ä !h!Ÿ!:"Õ$ú$7 4"2µÂ¼)Ï·
aÏUg
PåÈ°Õon ºkqMÔ …ïZm«òÖuy² 4 3!¥!Ú!,#q#$o$H ]¥
Gÿ %M!¢´¤@	R	ï	Q
p
‘
Ï
0itŸÝäµ¡24F`­Åû-�¢¤gÆìHUwÅÀÆùüÿ # M h ‘ × ™!œ!È!K"N"Ø"Ò#å#$‘$; Ç.!ƒå¹—
Õ
gÂ*¥Éðf¤…ÅÚ÷v¥©HåBl_‡²ûÁM‡<AFÑ)4â´€›ÅPÁl÷…“J!C"Ì"Ù$/ „ ÊþŠÃôøXÞ�	@
�
3§­îbó=äíý@s¶ÎÝø/j¥'6ýaqÁ"§W"i"o" › ° ‰ë)×7“9
=µÙ>~�L¿FÜRÆ	fõÙÐt$- Ñ ZÍVdŒñô&ä+$2ì	
†p›Î•˜=Y~–\t«(+@p,Ñä¬4P!á"¡#Â#$¡$) + ” A�™„T®Áã	D4”«Å@^y£j°™´h™Ø»�qÛ - O!þ!–"ä"ó$ Û;Å8šŽtxg‚7V«&•W`ÝâÇG _ s!'"Š"`$†$ € Ô ö  UýNn0G¿0¤k5v�¹aŒ ¶ j#( Kµ	è	´
€Œsà:�à:Íg„ã¶Œ˜\_€Ì¢?• Î Ú !
!"×#I$Ë$
% >ÝÓd¦—	%�BÝ !â!  ŠR™›l„WFãÃ÷ù®ÓioÒ“o£¥ž þ 8"J#Õ#Y$" L “ßMQ¨¦~Jc	ç
ñVcÜî(‘¶Ïeß>7Ì'!¥"�#�#i$+ þÚ{‘:àUùO	s	¤	²	xm'¸I;è½Ü^TöD w !U!"H" $[$š$¤$%%O R	4im�ª@Á:E	$	ø
ü
MZ›¢^ž¾ÐóJR+;´>DÚ	4à0Ey¸G†¡Ù$6T“Sæ†ßgÃ™ð¤¯¸Ë@a{ ¨ í Ã!Ñ!§"µ"’#¬#·#è#> £ ,`ºx¨
Aåk’ó	
ê¼=ny!�Û‰\¸R‚*bþQØêð�œïz`´Æõ_2záO9†×\!^"$1$}$ª$´$  å%^‹®Òq‹	u
VYÓ)6[4‹èÕÝ*:yç#!L$Ý$=  7OVßêí¥»¾_Ìé/	¿	Â	Ê	Ó	·ÄçCSJŸ²»[rÁÞŒð:iN„ŽSC¯K�ÀžTª.M€û c!@"c"¬"x$Á$ð$ if ¼uæƒ#
 y {¨}±æ˜S!  i £áçV§^	•ú?�¨ú“]u[¿9Ü:€aïIŒQ"~"y# Ð'—7J4	ˆ	ä
ËNk5_7XÑ¡«Ç¬]ïÈÿôY#e## jð¥Îð(é½Ö	T
é
ÑèÉ"¶ov|ßÏ}d0
£|çšäì!Î#¼$ < ã Y’Õ}
0cÔÝT�®Ëó#™˜DÒ"Ý"^#Å#C$Ñ$" N ë •‚@v×0È-?JZ‡^e©
õQÑ$e§õO§Ïd«m ˜ A#Þ#+ ­ þ ]SbRËDc€h°l‹
Ž
ˆçwÀv!\p’Ü;ÓÁB}ê )!p!y!Í!²"é"U#$  Ð [–Ÿ ›sc		
L
¿
(�++###ˆ#. ’ Xæü6‚ãPHLæ	_x³×NßeñZ&º5>ÚÄž3~ÿ³ÄÊÎô f!à!h#m$# .‰£ãæÊ		ö
UWÑÿ'5ïþ¸sLs¥¡­bw„k \#k${$' ¾èõÍ	”
Ò
‰‹‚Šåè7úóÿ*&‚ß•F'Qá& ³ 7!¶!“"À"ï"ü"## #@$Ä$ç$ Â´"e‡Ùó†oÛ)	“	z·Àµ¯¼õ!"ñ"þ"#"#5#Ç$é$ zr6<l¥­÷	u	Ï	²ê±ë…=Ÿ·) "$–$% Ù ·Á¶o{÷ÕDÛþ¹!Â"–#ã$% � Ø“ƒ˜Ÿâìü		Æ
X„Î0"5"¼"ù"#)#ý#]$ƒ$�$§$Î$A  °	´Á$³ Y?	Q	y	Ÿ	¦	¬	¸	3
o
�
Î
Î*ã„01$EK_õ!¬‡,^m‚`ÁfÊçËYHñÕÑVøL !:!W!Ç!Ù!J"×"ä#�$5 ˆUÉ-‰*WÖ¸8
?
–
Ô

oÍ)„ÄÙu•sªú'Í*?(á³ü`ÄÀkÀ!3Ø!I!V"h"n"Ë"Á#$ $$ :@Ä­â´	³
‹�ŒFx�˜gƒªµj%u—ŒpË>F ^ ‹ ” µ "‰"•" ÜP¥ z}cßøwƒ$ðV�µÎÑ’nŒSC !!T!I#8 ¢ ä­ÀÑ9^j.	ò	t
LY¶æxž±ºŒIQ*:q=C3FR…5’³¿ç1Ô£Ü)N`z § ú b!Ð!]"b"¶#$0$³$  h –6IùMZ—þHó }"X#d#$ â ê ý i¤au‘Ö,>I†¨
ô‡çµ�uc /o	À™ão!±"Ü"Í#Ý#
$B$ 
 ½žâåÉK
¾
^Ö'Ðäçþùý4=Þ2Eƒ²ÃÉß!¿" y¶!ÀµkëÚû(	¶ê¿Í„<( ¸!ô!ø"#(#4#ü#•$œ$¦$Æ$ #ÕX÷2
/EïD«l©´ÀÉæÊ¿¿2ÐŠ !9!g"Ö"À#$ g ¡ á é `¼�is
§
½
�°Ïã)9ütæ0±y Û"µ#Ü#	$²$ f x´hêWœ¯Cs;1‰ f"Ú#Û#”$  5Ð  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                2                                                                                                                                                     
                                                                                                                                                                                                                                                                                                                                                                                                    	                                                                                       	                                           
                                                                                     $                           $                          	                                                                    !          	                                                                          +                                   	      	                        	                  (      	   +   #      
                           <   ;   
         
            
         !   #               	      &      3            /                     %                           D         9   +      )   Ë   u      4   !      =      ˆ                                                                                                                                                           2                                                                     
                                                                                                                                                                                    	                               	                 
                               $         $          	                          !    	                          +             	  	        	      (  	 + #  
         < ; 
   
    
   ! #     	  &  3    /       %         D   9 +  ) Ë u  4 !  =  ˆ   “
  ”Ð  ”ø  •˜  ›B  £  «JçË¶$$’I!$'o†,>ì÷y	Îô$ÏÐ$=stÎ%u	’NL !!I!¸!5"(#ã$Ö
o‚TÄ†Jµ¹	µ%®MN�…Å!:"¸	%�g/!=j!"=Äg¼ÌÃ€#û@]W°_vµ$;='Þ	ƒ« 4X # áîÚ0!Ô.OŠdÓ!æ!´_$ôN_ã‘Ô(T·ë	E	Ì	Ü	å	Š
“
È
v‘
²®´óµ·ÒwJåWÉV¾0¢¿õþý e!›!Ñ"ÿ#$&$-$_$SÕ
/gu<Ö	w	
WÝ²#¤oÙ/!ŒÖ
ûaÝK¤eoÖ
¤o	Ý²ûÔ ;ÚŽ:®ÒTŸ	5€/Oš/..M8
ÀVø#=V@0]=V@0ä]×µ1K	##¾
¸=—²*ÃQô›°ÃQôó ÍC:	ì¢ /°.ü•ô"$#0#3…5’§ Ð!‚óFp	$åhW
içJG!°ô"$#0#.omäâÈ9!·	ƒE4Ï!3#è$·	ƒE4Ï!/°.ô"$#0#«
Æ„öð÷ @ Ñiá"#ú$-	µå¹pQa"øˆ
SM	¢	»ô,$� ˜ù"#‰Æ €õRôô�ÊQ!Ä!-"“#�A¦¡V P#‹#,ny!�bØê�z9\!DŽ
çwÓ)!@ ¾E#,$É!0ËSã"%;�ã	°RÙ'f$;f$Ú¿
¶+<#×³+þ9À;×L	³ë~#f$�Q!Ä!ÞUØ×ã	¤
°R³'t† *>¦ ,$¦—¿{ç"À‹ ‚ˆÊo	V
Ü®©?¦"«#lå‹JÌÂ	²5Á¡ŽSC¯Kï._ÑŽ¥É!,$´æb °ƒ¬
5S×ÞóM	¢	€³-m/»°±.UØOô´!í"ô"õ" #$#%#0#1#,$�^Ð4¸†6T“S†ß¯¨ í Ñ!‚ó*FjÎé¶çãg$“¼új«q³XÚü2
Ô
Lz*¶÷Ù)9c‚`/æ	ÄHŒ¯Vy !9!:!•"Ë"ñ"µ#¸³ò…´"#êQ Œ †’	ÕØGJM,‰Õå#D«Ö"û
ì	ú9Fwt…›û Ògª$ä$%•";�×L	ã	¤
°R³Ùë't† ~#f$* “ ƒSã"Ô
Ùc/	Ä•"Ë"Á Í^CÚ‘Ã>²õ#hïDš$¼ÀÄÜ	n
¢
Í
šÎn/|€ØH¾[ù a!Â!Æ!ã#ç#û#�$ü÷Œ!•"SÀªÄºã"ò$TeeqÇÒÞ±´æ|UØ## s1( ¤!+#MÜîÚ¶ü—K^=y8ã	°R'‡ ",�^nyÐ!�b4¸Øê†�6T“S†ßz¯9¨ í \!Ñ!DŽ
ç‚wó*ÓF)!GR	­ÅHUùü™!œ!K"ê»¿	çS»NÀP#‹#^«`$Ñ™À|×ØË�Ò ï!ºQzy>#;1ÑT™iÀù|]Ð×áê ÐØË�Ò ï!f$ * “ €ƒÍ ‚äj
�‹ÙT?^·»ðt3ƒ¸Þ,š®M´ë„' R ì +!"\"´"	##¦#LFÎ	©žÝ•Ñ]
ÿü@	ŸXû-wå#§$	[c	¿
ÌÂ	²ÁŽSC¯K.Ÿû-wå#ÑjÎãé¿
¶0Ëç´ Çþ!+p«!Ñ8øZ	ˆù¬p$=Ö;[ <Î»tT•eÇÞ 	9I|UØµF##frÓß	² r-8VÙK¹³À9YŸ	¸	3
LY*„IQ*:õ!=C3‡F^…5‚’`çH£V`z § :!W!Ð!¶#”5!å$— é»”e¼új%6¤ìº½þ¡³è¾	Á	î	/hžRI´ À�JëTvSÄ¿ûþ" g � ›!?"M"«"Ñ#$ï$ oM^­×Ø	&	+	l
Ë
V³´ûu@0d±Òä/‰ý]–!õ"%#1#ú#Â!ÙÚÛ(	z¶·¿¯ô!ñ""#4#Æ$é$‰l:	ì}&† 1ýr	&ç]%%oM+	Vû@0d±Ò/]õ"%#1#¤þ¡³î	/hž´ ëTvÄ¿ûþ" g � ›!M"Ñ#$6ìº½è¾	Á	RIÀ�JS?"«"ï$´	³
‹Œƒµ—Ë>” "7³
i
>þºÌ¤ïL+"„	Énö•#ò ×6Q¤ìº½þ�(ž¡³è	B	E	i	¾	Á	î	c
/hžRI´ ”Àƒ�JëTvSÄ¿ûþ" g � ›!/"4"?"M"«"»"Ñ#$‚$ï$Â!Ù³À9YÚÛ(	Ÿ	¸	3
LYz*„¶·IQ*:õ!=C3‡F^…¿5‚’`çH£¯V`z § :!W!Ð!ô!ñ""#4#¶#Æ$é$ßâ‹Í Ù !H$Ê$(àüÙ	`
y
´yÔ#]ˆ…"3$$Q3©?]�ò³Df˜Ê?¦"‘#«# ´ÁÎmYñÕÙ!6ëW	$
ÿ
(ý€³é£Yg„"µ	€àà
!"×#Ë$æ_xNßº>žÿ³Äô f!m$¨AR*œzÆõá/.»
q²ö"&#2#!$]3zŠ	Oä5¯Ô3jpÔÓC„î‚ÚýŽ$â$%< æ¨A_xNßR*º�>œ±zžÆõ˜á™ÿ³Äô f!m$2µÂ¼)·
aPÕ ºM ïò ¥!,#M¨¦ñÜî(eß>7¥"�#¾/!E#¬$¬îðóO ëûÍø"#(#ü#œ$¦$$H	È Üám¸ù 	

Â
—ˆÉíB‹”¦k€víôüb¶Âê$YÍŠÉì0 � ÎÕïÓ—#¤#ç_j(¯5–ä€	Î	
Y
í
yé!<OkéÏày�­»ñé,Lyªí‹Ÿ^�FÌž…Ir ã g!|$ù$ý a‡u oÀo!±"
$t8n{��¸ý?g|ú½ …!"GœÖ!<°ï;	É+[®»RÆõm\o×Ýí<%!¨#¼#ß$Á .|oÍ^“Cm›¦Æd—ÉÚä‘âþ0µÃ¿ã>úER²;‘4~ Ž!‘!"�"õ#Êb�
|è"T#Ü¸ 	
Â
—vá
ˆíÂ$Ö;	É[®Rõm\×Ý<%!¨#ß$mùÉB‹”¦k€íôüb¶êYÍŠÉì0 � ò ×Q�(ž	B	E	i	c
”ƒ/"4"»"‚$2M¨¦µÂ¼)·
añPÜî(Õ ºM eïßò>7 ¥!¥",#�#¾íßA¤š•šÎŽr. Sû8Ë—q!%"îØ Á"_ «˜â'íïý	h	º1"®$%%� Ø“ƒ˜Ÿâìü		Æ
X„Î0"5"¼"ù"#)#ý#]$ƒ$�$§$Î$` ò _¬Q>™z�(Ê$‹þB	E	H	i	c
9”ú·È 6$P$ù[	X™ª‰ú¡“­§´Ü!q$y¸%&T®�F¥»ç½	ä	R
’
Ð
 Q±ºåÎS3‡5¿.aÛRü(.î{�Ÿ×^Qäí)_xäRzÆ%8$ i !!O"?#æ#Û$î$^ ªûXáNü`£±Òî/	1	g	¹dž�¦¼Ê!2"®"$-$¯$%if ¼uæƒ#1Ufh–¨ýfrÀÈÓß		p	W
È1:$ÆiÝp²×µçþJå1!} r-8VÙK§¶G¯¹Þ##$ S^®x*<GõÇØ	&	6
m
Ì
J\"…÷´õvŽ2Ë±äŠŠñþ—ø !R!Å!."”#ú#Â´"e‡Ùó†oÛ)	“	z·Àµ¯¼õ!"ñ"þ"#"#5#Ç$é$+ ” A�™„T®Áã	D4”«Å@^y£j°™´h™Ø»�qÛ - O!þ!–"ä"ó$ Sy¸Â^gk…®º%Bmx¹!&T®*<G�£õF\q¥»ÇØçó	&	†	½	ä	ð	6
R
m
q
‰
’
¥
±
Ì
Ð
â
ô
ú
J\u °"Q…±ºå÷€Î%S´Ùõ%3Gv‡¯×Ý5=¿.aÏÛø$RŽ©ücq(.2Œî{ƒ�šŸ¯Ë�×IR^ÚQäóh±Çäí)_•ÈxäRzŠ—½ÆÍü%8nŠÉíuñþO—ÁÇ$ i ‡ ’ è ò ø !!!R!Z!`!m!w!´!Á!Å!".">"O"ª"º"Ð"Ù"í" #?#†#”#æ#ú#$Ž$’$º$Û$î$ + ˆ ” Ç ¤Û.;A�™Åè8:<„šWËThw¨®Áã	þ	¬
DÞ4Ž”ûýt«xÅ@^gy£j‚°kß”Ô,v™´$7Vh™õ:Í«­Øù&OQ•»ô%W`b…�ÒEqÝâäÇ
|Û - G _ Â O!s!¼!þ!'"R""Š"–"ä"`$b$†$ó$A �ö–&¬r£#<0ˆI£ò¿ÃÍêÃ	í	.³ûv\Â:ájÑ…�TD°LhGxSu†U/N_œ� ü ü!A"Ð#g$ñ$+*\8ƒ”ö	 
ñ�&MGOžBq§:¿ü¢9“ÑW q"Q#Œ#
 ½žâåÉK
¾
^Ö'Ðäçþùý4=Þ2Eƒ²ÃÉß!¿"m;©Äñ8	à
,ÕØûGJMƒõa»âT|,/KôbŠ‰¥PWxÕØCVŽ÷¯â+ˆê÷éùkïæ ð }!¡!¿!ç!"<":#ø#ü$$ ˜,LZ_“ÿ:p¥(1dÕÌÁ;cZ s"Æ#‹$! A F �y¸ö	k–%:�&5HT€®á�F¥»ç-	9	½	ä	R
’
Ð
X µå&Q±ºåw¹ÎøS¬ý3‡´5p¿ø.Ua}ÛBRü(2(.<YÆîQ{�Ÿb ×
^²DQÝäÿ.íó)1_irxÓä,Rz¢Æë%8G™$ i ¦ ¿ !!!Þ!è!O"a"?#£#æ#Û$î$ý$MñÒ
M
À
  ¸#=+�‚„ {!‰#  Z     	i  %9        %9T²Ïš©�¥‹a–X*é´ Þ« V#0_ù¨©ª¹YÚÕ˜›ÎØGY†V:ÖY¡Ua&µÚ¼‹?¦¿ª£ª>¾*£·ôW8!RUáFÒ€�Ä€§l^ítÂQ¾„J¬ÿ\ªõ†z¥Jã˜ƒ0šoÉ¡ÏQ5ì,ógy®Ñaè(Iíô·ESnœ6%i�#�eöwŒ=zzá×—Îª�×`¶%ìú(ðNö}\q2÷ø“X5×(Í^ix1yéîN¿u¥‘à`CT£A÷®3°þ¼88*há•¸Â .Ì&Ú4Þ ô`”þü›$¦çqÀÐ×˜\VGFÎ��·†”Ú	x´}JžÙ™êF†¥^¶ªZ•A¹Q¾ªnØ}Vþ—!*²½á2Ñÿ$UT®„oª«ŒÉn8èÕÕU÷Î}0‚¢£ÁµŸ^ê¯%àëM4gÕž+®H“É)}ëQ{‰7Ï�Ÿ³¸å¾)ôƒŽ= ÆRÈº|
µd§Á”3L, 
ÈÝÓôè�ñxF~tÈNa3Üëñ@ECBo	L4ÐDÍÄëÐ\ø&êd¾,
³ß¸z,j¢ì´ 0O˜\ô×0ú©Â¾ª8>¨íØ®¯Œ¦ÿ†¸�—É§Ï¨HNó³Í<\|LÓÒS?YÍ_>ïó2ƒÆ¶–4àÜt*üx04„ÍsZX„¤íí¤7ý§z˜ëÃ²bˆ�h„Á—Z·tÓ˜}†œõ:64>ãKÀoa8×;÷ó×{€óa¼ÏàüŒç‡Ó0}4žk°Ì2|}°pç‹WÃq‹ÐßEô]öôŽ4^;ÇŽ†14NÛ#O…¡I�uáìÄZ*�Ðõ‡Õ�[ìtèmÃFÓø†:}C®´ïQ5cú™SÛH¿±/4Nõçz-ààJßWbßHX¨ÓT�Ø ø ~´�4Ý¥Óß ÛÝ{Ûy³ƒNUµOŒÄVãŸJI…_Ž2ú„A�·ã8ÑvÚÐ÷/@FØ�µ‡ŒAŽ'ÇQw×líÐCë½œØK^)QUµ”á]EH}z/µ´ÛÓ­V„>f{�Ò k­}HÚ­¸TUŽ>z´ª¡D3KžÙøPôöÐQIÿŒucþ4ßŽÑµàEEÄE[èYÔËB4^‚WRåh�8Sì—ôyÑMei®Ñ;¸‡�]FÑVÈÙ@&øPu×4Ô‚rÀC(v:+ûˆ†Ûûï÷ƒÈ»£Q¡4žqOnƒ¸�};�µØQ>¾ç�†‡dE@ölõ8UÖ0ÐQ§aG<~„§iõ¶ÑY=C´F*a‡SYÒí+|côSiô‚ÚÓ¿ƒ›ý7ÑÒuá[{m�~=F-}–T–…}tEXu5Øá�8ÑF³CFDÞ1A‡»U~þäÑôë·Ý·HU¥ÄéDˆÑa­ÔÖŽ®×Ó¥Fc£×­®Iãš�š�æ­àU›X"�9éY:ct”ã½k½]v)P©…=ÞA^.>àeHéóˆU•V…èQK( ÷˜QÑyÑSôÑ½îÑëtÒoz˜n 5+UKwN85A‘•Ñ±êB˜àEumMhAi²y´:¸Ôƒ¹†9\óÐkéö¨¯]ÒØÂªE£t…fàÕÄumRuU£…ê3Öµ¥˜Nôàûg~Ðxî8]Ÿ›QØkKþ¸ãQ4b¶;	Úž�FàGšt+¥!áD¨náUŸQ±J QíÄc×°UâYEÕ¯�´_�ŸCDŠý+TÅ:1>…Ðá8,9MVäu#œ=YT^ÖFßÇ‡¦¡FDQE[ˆtj]Xy‡×�5bAè(4V‘.SÛPEœF…B„
ç�7ðQfa85CnY´ÕÒ'´ �DDúà…[T¾ÔuC�àA„ál�V×¹Ñ_@…tÏ�"]5kE‡ám Qíf¿5æ�Q‘lTHDDQtºA!õ4FÔE¡DB42S�¹ôwKt¤WEÎüfÑ^ÑÓ?fý±ý! |¡ß½N¨`8AEtÖ4îa"Ó†ÇU×è^hP´�E(ë…oOkë �æÎÛŽ»åV{¨$CÔEEim?E½ÒØë�ÐÓ�&Zý°XE8x±Ò=“°¶‡¬aòÓFf4ÑU9·‚¨a½ªÐÔt›Š´SÛQU¨hdE|3ã�OÑ£­ "IâHº¨õQ‹>ƒð††Dj&ÆþüFKEW¨�½-õTP´§#NÑl_vx.;£«IÑDSbúõ´uø‡ËxNIà™¡/xµ…à[‚Ñ«¦B‚”¾ô
ÔãdÐÙ�au]è6¦öh:KÇàž;�(àSõ4çƒ©’ø¤×¡
} AO�DBà€ÚµDS¾.4\N-à&Xo…tÛnê+ÔöP^Û@÷	¬é¤Stl×À¶‡õAÛ*}(vM™Dšµ„´„k»Fõ!†}Pj¨×xQVéù¸×•EF6”A]¸ºãîEÐ�·U´Éd¡ýõ•‹ŠÐCçQ@ùhi…~µEâ!4!`V_mÀm;ß@‚ø$dTt4´˜fµæ‡P>Š+¨m'ÆðÓí>ÞÖ£‡a»èU`‹ôÓM€Ò´Æª“NüvÒRQ«ßfôËAj_eÓº«G�E±?Ú4öêÑWàE[½§E	‘0²‡M·Ñ¸í�Ðƒm½ý}ÀôS‹zÐsK¿@ˆh}G`÷ÐáOŽÑSëd:Ä…QE´ÓD4…EVü˜CƒÓ:ø½'íÀBè¡ü�€A”ßSÛÁ@+d`ó<ÝãQßM9�U¾�õ_V•Y¾e=•³½‚E·€ã>¸óï"ËÔŸÓúuØºÃ¼üïüììïìïüÒü:‡=Ðºùîšùí©4’¹ 7�fäck1	ñ;·ƒË*�rÈx_àÊ^–Ï£MÛÿ«=82Y1D?7ÆÏëõÒŒÓá`Åƒ>Âj»éÍ¸Œ&­ß6`�îÒu¸îód¥=?Ç=wó‡3øp:.;ðÛÎ�N!òï8Ø‹D*·Ëmñ\Ì  ä  #†  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ö<?xml version="1.0"?><Features nextValidID="8"><Feature recentID="7" name="DSP" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="9095" maxFusedRunOn="9095"><Segment range="2277-9092" color="#ffcc00" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="6" name="lac operator" type="protein_bind" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="2182-2198" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="M13 rev" directionality="1" type="primer_bind" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="2206-2222" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="M13 fwd" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9135-9151" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="lac promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment name="-35" range="2144-2149" color="#ffffff" type="standard"/><Segment range="2150-2167" color="#ffffff" type="standard"/><Segment name="-10" range="2168-2174" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="96-200" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="1232-1820" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="RIGHT"/></Q></Feature><Feature recentID="0" name="AmpR" directionality="1" translationMW="31558.16" type="CDS" allowSegmentOverlaps="0" cleavageArrows="269" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment name="signal sequence" range="201-269" color="#ccffcc" type="standard" translated="1"/><Segment range="270-1061" color="#ccffcc" type="standard" translated="1"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  x<Notes>
<UUID>39ef7355-18e9-4879-bf39-ac07da229121</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pUC57</CustomMapLabel>
<Description>&lt;html>&lt;body>Cloning vector with an ampicillin resistance marker, suitable for generating ExoIII deletions.&lt;/body>&lt;/html></Description>
<Created UTC="16:0:0">2012.4.26</Created>
<LastModified UTC="8:35:18">2025.9.22</LastModified>
<AccessionNumber>Y14837</AccessionNumber>
<CreatedBy>GenScript</CreatedBy>
<Organism>Escherichia coli</Organism>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>Unspecified</TransformedInto>
</Notes>
   ©<StrandColors><TopStrand><ColorRange range="0..9528" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..9528" colors="black"/></BottomStrand></StrandColors>  %     	h  %6        %6T²Ïš©�¥‹a–X*é´ Þ« V#0_ù¨©ª¹YÚÕ˜›ÎØGY†V:ÖY¡Ua&µÚ¼‹?¦¿ª£ª>¾*£·ôW8!RUáFÒ€�Ä€§l^ítÂQ¾„J¬ÿ\ªõ†z¥Jã˜ƒ0šoÉ¡ÏQ5ì,ógy®Ñaè(Iíô·ESnœ6%i�#�eöwŒ=zzá×—Îª�×`¶%ìú(ðNö}\q2÷ø“X5×(Í^ix1yéîN¿u¥‘à`CT£A÷®3°þ¼88*há•¸Â .Ì&Ú4Þ ô`”þü›$¦çqÀÐ×˜\VGFÎ��·†”Ú	x´}JžÙ™êF†¥^¶ªZ•A¹Q¾ªnØ}Vþ—!*²½á2Ñÿ$UT®„oª«ŒÉn8èÕÕU÷Î}0‚¢£ÁµŸ^ê¯%àëM4gÕž+®H“É)}ëQ{‰7Ï�Ÿ³¸å¾)ôƒŽ= ÆRÈº|
µd§Á”3L, 
ÈÝÓôè�ñxF~tÈNa3Üëñ@ECBo	L4ÐDÍÄëÐ\ø&êd¾,
³ß¸z,j¢ì´ 0O˜\ô×0ú©Â¾ª8>¨íØ®¯Œ¦ÿ†¸�—É§Ï¨HNó³Í<\|LÓÒS?YÍ_>ïó2ƒÆ¶–4àÜt*üx04„ÍsZX„¤íí¤7ý§z˜ëÃ²bˆ�h„Á—Z·tÓ˜}†œõ:64>ãKÀoa8×;÷ó×{€óa¼ÏàüŒç‡Ó0}4žk°Ì2|}°pç‹WÃq‹ÐßEô]öôŽ4^;ÇŽ†14NÛ#O…¡I�uáìÄZ*�Ðõ‡Õ�[ìtèmÃFÓø†:}C®´ïQ5cú™SÛH¿±/4Nõçz-ààJßWbßHX¨ÓT�Ø ø ~´�4Ý¥Óß ÛÝ{Ûy³ƒNUµOŒÄVãŸJI…_Ž2ú„A�·ã8ÑvÚÐ÷/@FØ�µ‡ŒAŽ'ÇQw×líÐCë½œØK^)QUµ”á]EH}z/µ´ÛÓ­V„>f{�Ò k­}HÚ­¸TUŽ>z´ª¡D3KžÙøPôöÐQIÿŒucþ4ßŽÑµàEEÄE[èYÔËB4^‚WRåh�8Sì—ôyÑMei®Ñ;¸‡�]FÑVÈÙ@&øPu×4Ô‚rÀC(v:+ûˆ†Ûûï÷ƒÈ»£Q¡4žqOnƒ¸�};�µØQ>¾ç�†‡dE@ölõ8UÖ0ÐQ§aG<~„§iõ¶ÑY=C´F*a‡SYÒí+|côSiô‚ÚÓ¿ƒ›ý7ÑÒuá[{m�~=F-}–T–…}tEXu5Øá�8ÑF³CFDÞ1A‡»U~þäÑôë·Ý·HU¥ÄéDˆÑa­ÔÖŽ®×Ó¥Fc£×­®Iãš�š�æ­àU›X"�9éY:ct”ã½k½]v)P©…=ÞA^.>àeHéóˆU•V…èQK( ÷˜QÑyÑSôÑ½îÑëtÒoz˜n 5+UKwN85A‘•Ñ±êB˜àEumMhAi²y´:¸Ôƒ¹†9\óÐkéö¨¯]ÒØÂªE£t…fàÕÄumRuU£…ê3Öµ¥˜Nôàûg~Ðxî8]Ÿ›QØkKþ¸ãQ4b¶;	Úž�FàGšt+¥!áD¨náUŸQ±J QíÄc×°UâYEÕ¯�´_�ŸCDŠý+TÅ:1>…Ðá8,9MVäu#œ=YT^ÖFßÇ‡¦¡FDQE[ˆtj]Xy‡×�5bAè(4V‘.SÛPEœF…B„
ç�7ðQfa85CnY´ÕÒ'´ �DDúà…[T¾ÔuC�àA„ál�V×¹Ñ_@…tÏ�"]5kE‡ám Qíf¿5æ�Q‘lTHDDQtºA!õ4FÔE¡DB42S�¹ôwKt¤WEÎüfÑ^ÑÓ?fý±ý! |¡ß½N¨`8AEtÖ4îa"Ó†ÇU×è^hP´�E(ë…oOkë �æÎÛŽ»åV{¨$CÔEEim?E½ÒØë�ÐÓ�&Zý°XE8x±Ò=“°¶‡¬aòÓFf4ÑU9·‚¨a½ªÐÔt›Š´SÛQU¨hdE|3ã�OÑ£­ "IâHº¨õQ‹>ƒð††Dj&ÆþüFKEW¨�½-õTP´§#NÑl_vx.;£«IÑDSbúõ´uø‡ËxNIà™¡/xµ…à[‚Ñ«¦B‚”¾ô
ÔãdÐÙ�au]è6¦öh:KÇàž;�(àSõ4çƒ©’ø¤×¡
} AO�DBà€ÚµDS¾.4\N-à&Xo…tÛnê+ÔöP^Û@÷	¬é¤Stl×À¶‡õAÛ*}(vM™Dšµ„´„k»Fõ!†}Pj¨×xQVéù¸×•EF6”A]¸ºãîEÐ�·U´Éd¡ýõ•‹ŠÐCçQ@ùhi…~µEâ!4!`V_mÀm;ß@‚ø$dTt4´˜fµæ‡P>Š+¨m'ÆðÓí>ÞÖ£‡a»èU`‹ôÓM€Ò´Æª“NüvÒRQ«ßfôËAj_eÓº«G�E±?Ú4öêÑWàE[½§E	‘0²‡M·Ñ¸í�Ðƒm½ý}ÀôS‹zÐsK¿@ˆh}G`÷ÐáOŽÑSëd:Ä…QE´ÓD4…EVü˜CƒÓ:ø½'íÀBè¡ü�€A”ßSÛÁ@+d`ó<ÝãQßM9�U¾�õ_V•Y¾e=•³½‚E·€ã>¸óï"ËÔŸÓúuØºÃ¼üïüììïìïüÒü:‡=Ðºùîšùí©4’¹ 7¹ÚÌB|NÅ­àòÊ§\²Wø2Ÿ×¥³èÓvÿêÏN–LQÍñ³úýt£4øX1`Ï†0š®úsn#	«wÍ˜#{´�n;†<Ù)OOñßÏ]üáÌþ‹Žü6ó§GSˆ|»ÀN6"Ñ
­òÛ|W3  ä  #ƒ  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  Â<?xml version="1.0"?><Features nextValidID="8"><Feature recentID="7" name="DSP" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2277-9092" color="#ffcc00" type="standard"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="6" name="lac operator" type="protein_bind" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="2182-2198" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="M13 rev" directionality="1" type="primer_bind" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="2206-2222" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="M13 fwd" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9132-9148" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="lac promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment name="-35" range="2144-2149" color="#ffffff" type="standard"/><Segment range="2150-2167" color="#ffffff" type="standard"/><Segment name="-10" range="2168-2174" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="96-200" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="1232-1820" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="RIGHT"/></Q></Feature><Feature recentID="0" name="AmpR" directionality="1" translationMW="31558.16" type="CDS" allowSegmentOverlaps="0" cleavageArrows="269" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment name="signal sequence" range="201-269" color="#ccffcc" type="standard" translated="1"/><Segment range="270-1061" color="#ccffcc" type="standard" translated="1"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  x<Notes>
<UUID>39ef7355-18e9-4879-bf39-ac07da229121</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pUC57</CustomMapLabel>
<Description>&lt;html>&lt;body>Cloning vector with an ampicillin resistance marker, suitable for generating ExoIII deletions.&lt;/body>&lt;/html></Description>
<Created UTC="16:0:0">2012.4.26</Created>
<LastModified UTC="8:34:58">2025.9.22</LastModified>
<AccessionNumber>Y14837</AccessionNumber>
<CreatedBy>GenScript</CreatedBy>
<Organism>Escherichia coli</Organism>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>Unspecified</TransformedInto>
</Notes>
   ©<StrandColors><TopStrand><ColorRange range="0..9525" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..9525" colors="black"/></BottomStrand></StrandColors>  f     ¸  
–         
–T²Ïš©�¥‹a–X*é´ Þ« V#0_ù¨©ª¹YÚÕ˜›ÎØGY†V:ÖY¡Ua&µÚ¼‹?¦¿ª£ª>¾*£·ôW8!RUáFÒ€�Ä€§l^ítÂQ¾„J¬ÿ\ªõ†z¥Jã˜ƒ0šoÉ¡ÏQ5ì,ógy®Ñaè(Iíô·ESnœ6%i�#�eöwŒ=zzá×—Îª�×`¶%ìú(ðNö}\q2÷ø“X5×(Í^ix1yéîN¿u¥‘à`CT£A÷®3°þ¼88*há•¸Â .Ì&Ú4Þ ô`”þü›$¦çqÀÐ×˜\VGFÎ��·†”Ú	x´}JžÙ™êF†¥^¶ªZ•A¹Q¾ªnØ}Vþ—!*²½á2Ñÿ$UT®„oª«ŒÉn8èÕÕU÷Î}0‚¢£ÁµŸ^ê¯%àëM4gÕž+®H“É)}ëQ{‰7Ï�Ÿ³¸å¾)ôƒŽ= ÆRÈº|
µd§Á”3L, 
ÈÝÓôè�ñxF~tÈNa3Üëñ@ECBo	L4ÐDÍÄëÐ\ø&êd¾,
³ß¸z,j¢ì´ 0O˜\ô×0ú©Â¾ª8>¨íØ®¯Œ¦ÿ†¸�—É§Ï¨HNó³Í<\|LÓÒS?YÍ_>ïó2ƒÆ¶–4àÜt*üx04„ÍsZX„¤íí¤7ý§z˜ëÃ²bˆ�h„Á—Z·tÓ˜}†œõ:64>ãKÀo¹ÚÌB|NÅ­àòÊ§\²Wø2Ÿ×¥³èÓvÿêÏN–LQÍñ³úýt£4øX1`Ï†0š®úsn#	«wÍ˜#{´�n;†<Ù)OOñßÏ]üáÌþ‹Žü6ó§GSˆ|»ÀN6"Ñ
­òÛ|W3  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ³<?xml version="1.0"?><Features nextValidID="7"><Feature recentID="6" name="lac operator" type="protein_bind" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="2182-2198" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="M13 rev" directionality="1" type="primer_bind" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="2206-2222" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="M13 fwd" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2316-2332" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="lac promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment name="-35" range="2144-2149" color="#ffffff" type="standard"/><Segment range="2150-2167" color="#ffffff" type="standard"/><Segment name="-10" range="2168-2174" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="96-200" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="1232-1820" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="RIGHT"/></Q></Feature><Feature recentID="0" name="AmpR" directionality="1" translationMW="31558.16" type="CDS" allowSegmentOverlaps="0" cleavageArrows="269" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment name="signal sequence" range="201-269" color="#ccffcc" type="standard" translated="1"/><Segment range="270-1061" color="#ccffcc" type="standard" translated="1"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  x<Notes>
<UUID>39ef7355-18e9-4879-bf39-ac07da229121</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pUC57</CustomMapLabel>
<Description>&lt;html>&lt;body>Cloning vector with an ampicillin resistance marker, suitable for generating ExoIII deletions.&lt;/body>&lt;/html></Description>
<Created UTC="16:0:0">2012.4.26</Created>
<LastModified UTC="8:34:16">2025.9.22</LastModified>
<AccessionNumber>Y14837</AccessionNumber>
<CreatedBy>GenScript</CreatedBy>
<Organism>Escherichia coli</Organism>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>Unspecified</TransformedInto>
</Notes>
   ©<StrandColors><TopStrand><ColorRange range="0..2709" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..2709" colors="black"/></BottomStrand></StrandColors>  8      ¸  
–         
–³2¬!‡Uû‡v4ïÁ-Ó¢âS<ÑÔü´ËL À‹ àéyŒ6Ñ4hž#}˜Â!Yótc%UŸ6ÐÏk=­3^(Àû¬æœôàÅ@#�CR€—=«ô·¢UÇHZÄì'ìÅ�¹°oÀü±ãD>65:–Ø-“Š¾"¢›ÎÝkÝ×gÁM•"Tø>XHN^Ý¥£(ÎÞ?:½,~,�N6–Ã×3 D0¨É 3ºó¯³·‡³Œì,¬8Ã	´ííPÂYÂ›ÝÐ\ÐT]ˆMT=5PôÉU2Žª½�ï?þM·Ulsµ-ƒüteF}«ÿ�NþÈÎïŠñþ<éðgâóêïëLƒ:»díÎ$&í+�²³½Nˆ�Åÿò´ü|ã>›Â^lºõü%Ç¦Ïx4ÓÞ	tM˜�Â9Ñ+¡H ùyÃ�äQtš‚n3¸áOJ~°UD “ºÃWWß8$Â
ªŠ�M4iÌÑUPnÔQ¾¡º®p‡;H{r”¨-„iµT­ùê•¥VªVÖåI™„•è.)õŽ–Òß›´Æâæ¬­½’�‡¿Ë"F^qœŸnôŽ5†|Äs·Ã½›Me}=<4Rã^¦óïoKšZ(ðäII+=)d¨ÍrŠ=£�²·;,¨&¶´ï
ýqµJvÿbˆÕTÂ“¾°¾ñ²‹E%(<Ò)·¶
`ÓxÙkºx¶=¼”cªâIí}Kk„Y"c|J;£ðËYÀeŸ3Ý“EêU#¶Ú\®°UîÔ§Î(Fô¬b_ÞÈß×†ëMº§«}2®Ut5XóUPP1ÜŠ{gºú«Y¦…6¦Ð)¢í„Á�š…‰©Y]Y ¯3v¯ñT�~¹E}¦›aÚ_™U�É·þ¬  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  \<?xml version="1.0"?><Features recycledIDs="8,7" nextValidID="9"><Feature recentID="6" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="2441" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="1650-2441" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="2442-2510" color="#ccffcc" type="standard" translated="1"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="5" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="891-1479" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="4" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="2511-2615" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment name="-10" range="537-543" color="#ffffff" type="standard"/><Segment range="544-561" color="#ffffff" type="standard"/><Segment name="-35" range="562-567" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="379-395" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="489-505" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="513-529" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ¡<Notes>
<UUID>39ef7355-18e9-4879-bf39-ac07da229121</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pUC57</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Description>&lt;html>&lt;body>Cloning vector with an ampicillin resistance marker, suitable for generating ExoIII deletions.&lt;/body>&lt;/html></Description>
<Created UTC="16:0:0">2012.4.26</Created>
<LastModified UTC="7:47:47">2025.9.22</LastModified>
<AccessionNumber>Y14837</AccessionNumber>
<CreatedBy>GenScript</CreatedBy>
<Organism>Escherichia coli</Organism>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>Unspecified</TransformedInto>
</Notes>
   ©<StrandColors><TopStrand><ColorRange range="0..2709" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..2709" colors="black"/></BottomStrand></StrandColors>  pý7zXZ  æÖ´F !   t/å£àG´.] Ë‡ØÎf‘ƒÊý{3Ôé·Ú(1v%f M*	mj÷)p80çÌ*iÚ	´NY]Qó“�úF7î&ƒÕ!Ò÷Ànþ~Ö=³=AÜéÛÜÏÂÚøŽï(Ts�Ã½³ïŽ¬ÏŽQí$�¿hBE~/S7õô,-©†XÙ_ë•OfœZz­·Ð^,²¨ƒ›í¿>Ý	�'·
Œu	Àúv”€l,ØŠvÀR›´‘µ´që½k‘¼Ÿ.ÊInÁ2açø7QÀüh‰£å›Wólš‡÷eâ·º”xF¯%AR&$«·´ÞI�æj@@	`î0zØÚŸfKÓ./8s	uâl£óÏ]â©ŒMSõäÀ£sõ!úMœÞ©–O^ðî/à�ÕôFk~‘ÕîWè‚"K*nÊyOø ¡¯ÁðC‰é
(H5ˆNý ƒö‰ÄZv¤{ýŸí'C7—�Ð¼›�[ô±-GCØšä®ï:Îð
�-Üí™Œ€_hÒö}Ÿ¸÷@Ø?šxÚ:‘Êkèí¨n>R�°R`àœQå/Œ`Êm „ Ã€‹�¼;)¦;šÓÃüèìf~eØxÃ´‹½Úúwo ¦²•Q/Í_²Vóˆ¬öX�~U(Ó�šwBÚ2’Z­ày§¤Êæ´',à0Ùã0§[N°cqáDy˜®8ÒQ—ŒõzÜ|kiÙòÜuR¬/­¸²±ÅDNöI,Ãôù£]öfŠ¸HpŒLÿA€îÛk'zÑêk
Kˆü;z<l
Ä;ð¯�‰uô°¾Ü^ç–8·zãù“¬\Éûè‘˜1•ª‚?ñm€ óhëBƒ›˜16Ý1¦ç`\½NÝcðŠçÆnêc×
dqª„YŸæÜ§˜Èç.±«’
‰áÉº’&ZŠŸ»l�éº×§OŸÎF}¨aÐ2‡ÉþDSvÛ:„TAÎÊÃ¢Lþ|%VñÆ›áx3ü8¼›—³l�ó&8çk´½Y+Kç>ŸIP½E+µ²eÙEÇ·*~)wÐú�XÙŠ/C|Vu±Ñ¯í&È›—êU~À2Âç¸ÉòÊ{±›t7?ñZoE~ Ý_o³=“ó"ß÷ùòìx,Ö	´ÔVÖs�–&±À3ã²_�©É	$,Q)SÃ0òYð.ÿØdZº,-Ñ<O¸¾ÛÐ•@Ø×A‚ÃÙÒ É^ÊY‹»ý;à2)Þº]ß‡ê3‘cUXD)æ.[`#ŸÿÅE©,4ÏÎ”ÀÅ4nVÖÈ™ÁPÎÿ~è—*ck,r°dümP\½ð3tAT’¿Ç÷(›kQ‰<E¡¤-Áÿ]f>>[yz”Gmˆs¾“jqp6Çýy‘Ì‘äa	¦L¦äÒú«R¾Täwù„€GøÓ“pLD2ôJ&WBBU!åÒYëÇ—Š�‰3-¢ÕÅû<ÏHà±ì4Â­
�•ï(¯…ÿu“ú¤3ücë‹Í7MÂa·yì€3¨&Vëo�
½Ëd KíÂR˜¼Œ¶lœ‹8ù"N°V=ýÚ;²‘.Ý2[
�æ¸)lbâzB›†ÙÌàn’ôOfù.<OnG§ú}¨ ^‡™0mBêÄt³Ÿ[›¡óô1¹”.æ?'˜µ0Üy�^àzÀ3DÝÀTÌÏùáÜ4ø·È†¹<â0Hö&í~9ã“ÒÚå|G/HºîôÕ´b·UÀÓç¿v0Æ¦aÒÊÂ¦(>úZ\Ûð›_W}±@èÇ„EKe^×´å©IÔb^ÔÑN“éþFM¨F[GÄ&ñ†Ò4Ž\aÙ„¢;æ,§<8-Pß9´�Þt¬j(Ï3X¶UÆš&1Ô4ïó¸úb>>Ye	ÐÍ.ÇÐo$§›6OzÕu*û®¬Ã.U×/sDk9åF'ÈÅ³¦£Ò´|ØÊäì—«E¾7/­,�«aTUì{¾!4Z¿¬˜àäUWÞtÃ^G¤CD´9XX0BjF«ê/�ýsNX<Ä9BžgË?Ì´m'±ÐUTøXØà˜emÃu7b¡}…2�D›ì‰e�ß—ˆkáês™`–Ö²UÄDÚVN„GRÓÚ<+c`;J²~vö‘ñaNàuäýð´‹±G~n…¤&ÍúÄ“0Jù¡é¶Tdê‹Y+‘íò{#¤Š8Åö°„ã«1ÆC pŠÕìLÊ¥_ÈåbRÆ²ðc�÷’€q“®#-âõ/ &I‹Þë‡€½¢¹×¦˜~”ô-æqÿ¡WOŸsÞ«íèªvA!¦Ðº¿w†´qŸ	i}ÖÙ8\xÜîÍ*#íºäðTL‚b”+Üo þÈ!÷b–ŠE8�…%°…™<«~ò²HtaæðŒ?í‘ÅêQ´ „ô®ºªD<°«�Î¿ý½³[%<ERÿ™§¤>cwbxÜýTò‹T;÷èM-Ýãýùð¼iSY×ã�"xõ”´YâT=î†d¹êˆ„ÂÆ‘ŽÊ½HA€!ñ“‡Ë¥*€y.,lÚ–12¬Bô�ø�PÄ²qH´li<çí²½nòr1êüWz*÷W¼{qyR¦\uí¸ß¾ÝMíÍ!,-•K_üü?øÒõÁ@‡É(;J“`Iî5YÈdNÃê¡~"ÿ£/œMÿë†­K“`|öb�í`ê·!YÔ-7Y;KÄ/Ì-À´cm%ª›uÂ7øÃÖ�ó1»š‚ª9âKE–qsŒ¿<›¢y×ÿº\C–CP‚¶.ý½ïy�À‡Éæ®ífŸÊR4ŒÊÆH�+	½L=·sò/\ÜËMi;PK�â®‚ËBc}o1Óœ
#£†$:0ù:Ã´¥ù%AÁóy¦V+lD
}r	M¼/´-àÍgL–âE«k�Û™�Fî�‹K¦°–Ž§h¾xËòƒ‚‚ŸÂmq!mOQN[ÈúV}©D½²Út@¦&?qAýYÐ
õ¶�ë{T4‹¼?d 7Yø‡‡Î/õ:eÿU+e €=(bQu óû%É/^T}£îi¹{&è@ÿÇ/B®Ö�P4Y'm@â�4Oî9§µU$=¹”p;ñ¤Nß!{ó#ïªÈ ÏCqƒñò#!TÏ¯W×²#÷¾u¾+†Áé…hÅ÷Ä!Dùæ;Ù„“Üx,ë=hÞÜµÏƒÿväÅðé¹^°L™UÔŠü€Z~ƒèø§'EéyçÃ1^Ñ©¯¼{®uÌ¼åo}uÊ=ôgÈí—0.CØ)O1÷ÙK}]a«M¡ÔŸPÙCÇÞÄo�ñ�y>^løOM,R.
9z`ÚEèlXt—+ót˜ Œêýç¯NXá0Qw»Ã ®MOé!f,(F¿+HŽUJfœ�ßi
è!núWwÓ{¬‡&§ðnKøv` Œç ¢÷¬Ôyiå¤7š�%©³wšÌO.K¾·”Æd²)-b”‰LÆ.ü†4»¾¢§¶K¡^ÛÅN-‚ƒ…¿ÑÐ¹ÈaUÿŽÔ·„¨'ãÓ[Ä�iæ?l Ãc@ôMõ÷Ž¹$™@I¼Ê¼X#¿øµ(=¿þœU2kÞðÜxÛm•Á7¥vÆ‹3“CpÇõf*Î’:€%„.¢Å\IU�ùlÌI-ÌìÒÃïTôòÎˆÞ¢n¨xZ—~º57$ý*ñ^ðW­Ûfw+ ‚i>Óy�ÒQÐûüåîO?[)¹v
Å‘W9“¹‡Y§ÕÐØ¼RkÂúDXgúp½«üïB£œB4Ï N!QÐ/ÌÚ½PL    ¡¾ñƒXzr Êµ� yXXE±Ägû    YZ   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  \<?xml version="1.0"?><Features nextValidID="8"><Feature recentID="0" name="DSP" directionality="1" translationMW="260125.50" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="9095" maxFusedRunOn="9095"><Segment range="2277-9092" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTGTMSRHQNQNTIQELLQNCSDCLMRAELIVQPELKYGDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYSFSSSSIGH"/></Q></Feature><Feature recentID="1" name="lac operator" type="protein_bind" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="2182-2198" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="M13 rev" directionality="1" type="primer_bind" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="2206-2222" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="M13 fwd" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9106-9122" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="lac promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment name="-35" range="2144-2149" color="#ffffff" type="standard"/><Segment range="2150-2167" color="#ffffff" type="standard"/><Segment name="-10" range="2168-2174" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="AmpR promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="96-200" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="1232-1820" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="AmpR" directionality="1" translationMW="31558.16" type="CDS" allowSegmentOverlaps="0" cleavageArrows="269" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment name="signal sequence" range="201-269" color="#ccffcc" type="standard" translated="1"/><Segment range="270-1061" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ­<Notes>
<UUID>39ef7355-18e9-4879-bf39-ac07da229121</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pUC57-DSP(human)</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Description>&lt;html>&lt;body>Cloning vector with an ampicillin resistance marker, suitable for generating ExoIII deletions.&lt;/body>&lt;/html></Description>
<Created UTC="16:0:0">2012.4.26</Created>
<LastModified UTC="13:42:37">2026.3.17</LastModified>
<AccessionNumber>Y14837</AccessionNumber>
<CreatedBy>GenScript</CreatedBy>
<Organism>Escherichia coli</Organism>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>Unspecified</TransformedInto>
</Notes>
  Y      K         
?????                                                                                                       ÿ d      DO  P               E              ÿÿÿÿYô? P                                                                                                                                                             <StrandColors><TopStrand><ColorRange range="0..2273" colors="black"/><ColorRange range="2274..2286" colors="green"/><ColorRange range="2287..9091" colors="black"/><ColorRange range="9092..9098" colors="blue"/><ColorRange range="9099..9499" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..2273" colors="black"/><ColorRange range="2274..2286" colors="green"/><ColorRange range="2287..9091" colors="black"/><ColorRange range="9092..9098" colors="blue"/><ColorRange range="9099..9499" colors="black"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
